Acide meclofenamique [INN-French]

Acide meclofenamique [INN-French] Brand names, Acide meclofenamique [INN-French] Analogs

Acide meclofenamique [INN-French] Brand Names Mixture

No information avaliable

Acide meclofenamique [INN-French] Chemical_Formula

C₅H₄N₄S

Acide meclofenamique [INN-French] RX_link

http://www.rxlist.com/cgi/generic2/mercaptopurine.htm

Acide meclofenamique [INN-French] fda sheet

Acide_meclofenamique_[INN-French] FDA

Acide meclofenamique [INN-French] msds (material safety sheet)

Acide_meclofenamique_[INN-French] MSDS

Acide meclofenamique [INN-French] Synthesis Reference

No information avaliable

Acide meclofenamique [INN-French] Molecular Weight

152.178 g/mol

Acide meclofenamique [INN-French] Melting Point

313 ^oC

Acide meclofenamique [INN-French] H₂O Solubility

6.85 mg/mL

Acide meclofenamique [INN-French] State

Solid

Acide meclofenamique [INN-French] LogP

0.335

Acide meclofenamique [INN-French] Dosage Forms

Tablet (50-mg, scored) for oral administration

Acide meclofenamique [INN-French] Indication

For remission induction and maintenance therapy of acute lymphatic leukemia.

Acide meclofenamique [INN-French] Pharmacology

Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.

Acide meclofenamique [INN-French] Absorption

Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.

Acide meclofenamique [INN-French] side effects and Toxicity

Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD₅₀ of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.

Acide meclofenamique [INN-French] Patient Information